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Keywords: acute lung injury; and bronchopulmonary dysplasia; aryl hydrocarbon receptor; chronic obstructive pulmonary disease; hyperoxia.

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Return to the sea.

Главная героиня новой ленты Мелоди — дочь русалочки Ариэль и принца Эрика. Как ни пытались родители уберечь дочь от неприятностей, которые таит в себе море и его обитатели, у них ничего не вышло. Мелоди сбежала в море и встретилась с Морганой, сестрой злой морской ведьмы Урсулы. Но маленькая Мелоди любила Атлантику всем сердцем, и ее любовь помогла ей преодолеть опасности и обрести новых друзей…

The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor that is well-known for regulating xenobiotic metabolism. Studies in knockout and transgenic mice indicate that the AHR plays a vital role in the development of liver and regulation of reproductive, cardiovascular, hematopoietic, and immune homeostasis. In this focused review on lung diseases associated with acute injury and alveolar development, we reviewed and summarized the current literature on the mechanistic role(s) and therapeutic potential of the AHR in acute lung injury, chronic obstructive pulmonary disease, and bronchopulmonary dysplasia (BPD). Pre-clinical studies indicate that endogenous AHR activation is necessary to protect neonatal and adult lungs against hyperoxia- and cigarette smoke-induced injury. Our goal is to provide insight into the high translational potential of the AHR in the meaningful management of infants and adults with these lung disorders that lack curative therapies.

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Источники:

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